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168 Recent studies also show that knocking down PPAR coactivator 1α (PGC1α), an important transcriptional coactivator regulating CPT1A and CPT1B, obviously decreases the ratio of NADPH/NADP + and ATP levels, impairing radiation resistance in nasopharyngeal carcinoma (NPC) cells

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Inspired by these natural features, researchers have introduced non-native disulfide bridges to reinforce protein architecture